SML2132
巴西木素
anti-inflammatory agent
别名:
苏枋精, (+)-Brazilin, 7，11b-二氢苯并[b]茚并[1,2-d]吡喃-3,6a，9,10（6H）-四醇, NSC 56652, （6aS，11bR）-7,11b-二氢-苯并[b]茚并[1,2-d]吡喃-3,6a，9,10（6H）-四醇, 6,6a，7,11b-四氢-3,6a，9,10-四羟基茚并[2,1-c]色烯, 天然红24
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关于此项目
经验公式（希尔记法）:
C16H14O5
化学文摘社编号:
分子量:
286.28
NACRES:
NA.77
UNSPSC Code:
12352200
EC Number:
207-477-6
MDL number:
Colour Index Number:
75280
产品名称
巴西木素,
SMILES string
O1C[C@]2([C@@H](c4c1cc(cc4)O)c3c(cc(c(c3)O)O)C2)O
InChI
1S/C16H14O5/c17-9-1-2-10-14(4-9)21-7-16(20)6-8-3-12(18)13(19)5-11(8)15(10)16/h1-5,15,17-20H,6-7H2/t15-,16+/m0/s1
InChI key
UWHUTZOCTZJUKC-JKSUJKDBSA-N
optical activity
[α]/D 108.0 to 133.0°, c = 0.5 in methanol
color
white to very dark brown
solubility
DMSO: 2 mg/mL
storage temp.
2-8°C
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相关类别
Biochem/physiol Actions
巴西木素是一种天然的异黄酮类红色素，具有许多生物学活性，包括神经保护、抗炎、抗菌、抗增殖和抗氧化特性。人们认为其某些活性是由于其对转录因子NF-ΚB的调节．
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yanyan Jia et al.
International journal of molecular medicine, 38(1), 210-216 (2016-06-02)
Renal ischemia-reperfusion (I/R) injury is associated with high morbidity and mortality as there is currently no available effective therapeutic strategy with which to treat this injury. Thus, the aim of this study was to investigate the potential protective effects of
Zhan-Yuan Li et al.
Inflammation, 40(4), 1365-1374 (2017-05-13)
Hyperglycemia and inflammation play important roles in the pathogenesis of diabetic nephropathy (DN). Brazilin might be an effective pharmacological agent against hyperglycemia and inflammation. In our present study, we explored whether brazilin mitigated pathological progression, inflammation, and extracellular matrix (ECM)
Eun Byeol Lee et al.
Archives of pharmacal research, 40(7), 825-835 (2017-07-02)
This study contributes to the continual discovery of lifespan-extending compounds from plants, using the Caenorhabditis elegans model system. An ethyl acetate soluble fraction of methanol extract from the heartwood of Caesalpinia sappan showed a significant lifespan-extending activity. Subsequent activity-guided chromatography
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