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SML2134

Sigma-Aldrich

Finafloxacin

≥95% (HPLC)

别名:

8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

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10 MG
CN¥983.78
50 MG
CN¥3,963.99

CN¥983.78

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10 MG
CN¥983.78
50 MG
CN¥3,963.99

About This Item

经验公式（希尔记法）:
C20H19FN4O4
CAS Number:
209342-40-5
分子量:
398.39
UNSPSC代码:
12352200
NACRES:
NA.77

CN¥983.78

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方案

≥95% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

−20°C

SMILES字符串

Fc1cc2c([n](cc([c]2=O)C(=O)O)C5CC5)c(c1N3C[C@@H]4NCCO[C@H]4C3)C#N

InChI

1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1

InChI key

FYMHQCNFKNMJAV-HOTGVXAUSA-N

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此商品
SML1608SML2795SML1581
Finafloxacin ≥95% (HPLC)

SML2134

Finafloxacin

Besifloxacin hydrochloride ≥98% (HPLC)

SML1608

Besifloxacin hydrochloride

IMP-1700 ≥98% (HPLC)

SML2795

IMP-1700

Moxifloxacin hydrochloride ≥98% (HPLC)

SML1581

Moxifloxacin hydrochloride

form

powder

form

powder

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 5 mg/mL, clear (warmed)

color

white to beige

color

white to light brown

color

white to beige

color

white to beige

生化/生理作用

Finafloxacin is a fluoroquinolone antibiotic approved by the FDA in 2014 for treating swimmer′s ear. Its mechanism of action involves the inhibition of bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV
Fluoroquinolone antibiotic

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H340,H361f

危险分类

Muta. 1B - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000230822
    0000230822
    0000127619
    0000041846
    0000041845

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    Jung Won Lee et al.
    Antimicrobial agents and chemotherapy, 59(12), 7629-7636 (2015-09-30)
    Finafloxacin is a novel fluoroquinolone with improved antimicrobial efficacy, especially in an acidic environment. The efficacy of finafloxacin for the inhibition of Helicobacter pylori infection was compared with the efficacies of levofloxacin and moxifloxacin at neutral and acidic pH. The
    Finafloxacin overcomes Burkholderia pseudomallei efflux-mediated fluoroquinolone resistance.
    Linnell B Randall et al.
    The Journal of antimicrobial chemotherapy, 72(4), 1258-1260 (2017-01-01)
    Will Stubbings et al.
    Antimicrobial agents and chemotherapy, 55(9), 4394-4397 (2011-06-29)
    Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were

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