SML2138
IR415
≥98% (HPLC)
别名:
N-(2,4-Difluorophenyl)-N′-[3-(1H-imidazol-1-yl)propyl]-thiourea
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
S=C(NC1=C(F)C=C(F)C=C1)NCCCN2C=NC=C2
InChI
1S/C13H14F2N4S/c14-10-2-3-12(11(15)8-10)18-13(20)17-4-1-6-19-7-5-16-9-19/h2-3,5,7-9H,1,4,6H2,(H2,17,18,20)
InChI key
KRSBPLFMLHNMPU-UHFFFAOYSA-N
生化/生理作用
HBx is a viral suppressor of host defenses consisting of RNAi-based silencing of viral genes. It is important for HBV replication and also functions as an RNAi suppressor protein. HBx is considered as emerging target for anti-viral therapy.
selective inhibitor of Hepatitis B Virus X Protein (HBx)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Subhanita Ghosh et al.
The Journal of biological chemistry, 292(30), 12577-12588 (2017-06-07)
Persistent or chronic infection with the hepatitis B virus (HBV) represents one of the most common viral diseases in humans. The hepatitis B virus deploys the hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of
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