SML2140
TCS 401
≥98% (HPLC)
别名:
2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride, TCS-401, TCS401
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关于此项目
经验公式（希尔记法）:
C10H10N2O5S · xHCl
化学文摘社编号:
分子量:
270.26 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
0.1 M NaOH: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
[s]1c2c(c(c1NC(=O)C(=O)O)C(=O)O)CC[N+H2]C2.[Cl-]
InChI key
LQGCAMWQDSYOAY-UHFFFAOYSA-N
Biochem/physiol Actions
Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B); insulin receptor sensitizing agent.
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B), which plays a key role in the negative regulation of the insulin signaling pathway, contributing to insulin resistance. It exhibited Ki values of 290 nM for PTP1B, with greater than 100-fold or more selectivity compared to other phosphatases. Inhibition of PTP1B by TCS 401 has been shown to sensitize the insulin signaling pathway and increase dopamine release in response to insulin. TCS-401 has also been shown to promote endothelial cell motility and to induce differentiation of retinal pigment epithelial cells toward improved contractility and motility.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable