SML2142
Silodosin
≥98% (HPLC), alpha 1-adrenoceptor antagonist, powder
别名:
1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide, Rapaflo, Rapallo, Silodyx, Urief
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关于此项目
经验公式（希尔记法）:
C25H32F3N3O4
化学文摘社编号:
分子量:
495.53
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
Silodosin, ≥98% (HPLC)
InChI
1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1
SMILES string
NC(C1=CC(C[C@@H](C)NCCOC2=C(OCC(F)(F)F)C=CC=C2)=CC3=C1N(CCCO)CC3)=O
InChI key
PNCPYILNMDWPEY-QGZVFWFLSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Selective alpha 1-adrenoceptor antagonist
Silodosin is a selective alpha 1-adrenoceptor antagonist with high affinity for the ?1A adrenergic receptor, used clinically for the treatment of benign prostatic hyperplasia (BPH).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT RE 2
target_organs
Liver
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Takashi Yoshida et al.
Urology, 106, 153-159 (2017-04-23)
To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil for patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH) treated with the α We analyzed 103 patients with LUTS/BPH with
Claus G Roehrborn et al.
Advances in therapy, 33(12), 2110-2121 (2016-11-05)
Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α
Hui Ding et al.
Renal failure, 38(9), 1311-1319 (2016-11-04)
To evaluate the efficacy of Silodosin as a medical expulsive therapy of ureteral stones, we searched PubMed, EMBASE, the Cochrane Library, and CBM up to June 2015. All randomized controlled trials (RCTs) were identified in which patients were randomized to
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