SML2155
TAK-901
≥98% (HPLC)
别名:
5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide, TAK 901
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关于此项目
经验公式（希尔记法）:
C28H32N4O3S
化学文摘社编号:
分子量:
504.64
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(CC)c1cc(ccc1)c2c3c([nH]c5ncc(cc53)C)c(c(c2)C(=O)NC4CCN(CC4)C)C
InChI
1S/C28H32N4O3S/c1-5-36(34,35)21-8-6-7-19(14-21)23-15-22(28(33)30-20-9-11-32(4)12-10-20)18(3)26-25(23)24-13-17(2)16-29-27(24)31-26/h6-8,13-16,20H,5,9-12H2,1-4H3,(H,29,31)(H,30,33)
InChI key
WKDACQVEJIVHMZ-UHFFFAOYSA-N
Biochem/physiol Actions
TAK-901 is a potent and tight-binding Aurora B kinase inhibitor. TAK-901 targets multiple kinases in vitro, but appears to mainly target Aurora B in cells and in vivo. TAK-901 suppresses cellular histone H3 phosphorylation and induced polyploidy.
potent and tight-binding Aurora B kinase inhibitor
存储类别
11 - Combustible Solids
wgk
WGK 3