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Merck
CN

SML2156

Sigma-Aldrich

埃罗替尼 盐酸盐

≥98% (HPLC), EGFR kinase inhibitor, powder

别名:

774 盐酸盐, CP-358, N-(3-乙炔基苯基)-6,7-双(2-甲氧基乙氧基)喹唑啉-4-胺, OSI-744 盐酸盐

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关于此项目

经验公式(希尔记法):
C22H23N3O4 · HCl
化学文摘社编号:
分子量:
429.90
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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产品名称

埃罗替尼 盐酸盐, ≥98% (HPLC)

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

−20°C

SMILES字符串

Cl.N(c3cc(ccc3)C#C)c1ncnc2c1cc(c(c2)OCCOC)OCCOC

InChI

1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

InChI key

GTTBEUCJPZQMDZ-UHFFFAOYSA-N

一般描述

盐酸厄洛替尼是一种抗肿瘤药物。它调节雷帕霉素(mTOR)抑制的机制靶点、表皮生长因子受体下调和表皮间质转化(EMT)抑制。

应用

盐酸厄洛替尼已被用于激活人 PANC-1 胰腺癌细胞系中的线粒体片段化。

生化/生理作用

EGFR 激酶抑制剂;抗肿瘤
盐酸埃罗替尼是受体酪氨酸激酶 EGFR(表皮生长因子受体)的抑制剂。它在临床上用于治疗非小细胞肺癌(NSCLC)和联合治疗转移性胰腺癌。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways
Wan J, et al.
Cancer Cell International, 18(1), 165-165 (2018)
Jorian D Hapeman et al.
Scientific reports, 14(1), 19980-19980 (2024-08-31)
Most cancer-related deaths are due to the spread of tumour cells throughout the body-a process known as metastasis. While in the vasculature, these cells are referred to as circulating tumour cells (CTCs) and can be found as either single cells
Kandasamy Saravanakumar et al.
Carbohydrate polymers, 245, 116407-116407 (2020-07-29)
The present work was developed the pH dependent-aptamer AS1411 (APT) decorated and erlotinib (En) loaded chitosan nanoparticles (CSNPs) for promising non-small-cell lung carcinoma (NSCLC) treatment. The characterization studies revealed that formulated APT-En-CSNPs were spherical in shape with size of 165.95
Analytical Methods for Therapeutic Drug Monitoring and Toxicology (2011)
J D Moyer et al.
Cancer research, 57(21), 4838-4848 (1997-11-14)
The epidermal growth factor receptor (EGFR) is overexpressed in a significant percentage of carcinomas and contributes to the malignant phenotype. CP-358,774 is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM and reduces EGFR

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