SML2187
RL5a
≥98% (HPLC)
别名:
N2-[2-(2-Furanyl)-4-quinolinyl]-N1,N1-dimethyl-1,2-ethanediamine
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关于此项目
经验公式（希尔记法）:
C17H19N3O
化学文摘社编号:
分子量:
281.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
RL5a, ≥98% (HPLC)
SMILES string
N(CCNc1c2c(nc(c1)c3[o]ccc3)cccc2)(C)C
InChI
1S/C17H19N3O/c1-20(2)10-9-18-15-12-16(17-8-5-11-21-17)19-14-7-4-3-6-13(14)15/h3-8,11-12H,9-10H2,1-2H3,(H,18,19)
InChI key
CRGKLHXVNVZAPA-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to very dark brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
RL5a is a potent inhibitor of the replication licensing system in human cells. RL5a blocks the binding of the origin recognition complex (ORC) to origin DNA, which is required interaction for licensing. RL5a appears to act as noncompetitive inhibitor of ORC with respect to ATP.
potent inhibitor of the replication licensing system.
存储类别
11 - Combustible Solids
wgk
WGK 3
Nicola J Gardner et al.
Cell chemical biology, 24(8), 981-992 (2017-08-07)
In late mitosis and G
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