SML2198
sAJM589
≥98% (HPLC)
别名:
5-Hydroxybenzo[a]phenazine, Benzo[a]phenazin-5-ol
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C16H10N2O
化学文摘社编号:
分子量:
246.26
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI key
WZBDRAAGHRCRKM-UHFFFAOYSA-N
SMILES string
OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
−20°C
Biochem/physiol Actions
Myc inhibitor that disrupts the Myc-Max heterodimer
sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Seung H Choi et al.
ACS chemical biology, 12(11), 2715-2719 (2017-10-05)
Myc plays important roles in cell cycle progression, cell growth, and stem cell self-renewal. Although dysregulation of Myc expression is a hallmark of human cancers, there is no Myc targeted therapy yet. Here, we report sAJM589, a novel small molecule
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持