SML2198
sAJM589
≥98% (HPLC)
别名:
5-Hydroxybenzo[a]phenazine, Benzo[a]phenazin-5-ol
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关于此项目
经验公式（希尔记法）:
C16H10N2O
化学文摘社编号:
分子量:
246.26
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
InChI key
WZBDRAAGHRCRKM-UHFFFAOYSA-N
Biochem/physiol Actions
Myc inhibitor that disrupts the Myc-Max heterodimer
sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable