SML2199
L-F001
≥98% (HPLC)
别名:
5-(3R)-1,2-Dithiolan-3-yl-1-[hexahydro-4-(5-isoquinolinylsulfonyl)-1H-1,4-diazepin-1-yl]-1-pentanone
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关于此项目
Assay:
≥98% (HPLC)
Form:
oil
Storage condition:
desiccated
assay
≥98% (HPLC)
form
oil
storage condition
desiccated
color
colorless to light brown
storage temp.
2-8°C
SMILES string
O=C(CCCC[C@@H]1CCSS1)N2CCN(S(C3=CC=CC4=C3C=CN=C4)(=O)=O)CCC2
InChI
1S/C22H29N3O3S3/c26-22(8-2-1-6-19-10-16-29-30-19)24-12-4-13-25(15-14-24)31(27,28)21-7-3-5-18-17-23-11-9-20(18)21/h3,5,7,9,11,17,19H,1-2,4,6,8,10,12-16H2/t19-/m1/s1
InChI key
NWTRUKNNHUXONB-LJQANCHMSA-N
Biochem/physiol Actions
L-F001 is a multifunctional, brain penetrant and potent Rho-associated protein kinase (ROCK) inhibitor that protects the PC12 cells from paraquat induced cytotoxicity. L-F001 suppresses neuroinflammation in vitro and in vivo.
multifunctional, brain penetrant and potent Rho-associated protein kinase (ROCK) inhibitor
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable