SML2207
SR-4995
≥98% (HPLC), adipose triglyceride lipase(ATGL) activator, powder
别名:
CID 16016685, N-Butyl-N′-(10,11-dihydro-10-methyl-11-oxodibenzo[b,f][1,4]thiazepin-8-yl)urea
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
产品名称
SR-4995, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
CN1C(C(C=CC=C2)=C2SC3=C1C=C(NC(NCCCC)=O)C=C3)=O
InChI
1S/C19H21N3O2S/c1-3-4-11-20-19(24)21-13-9-10-17-15(12-13)22(2)18(23)14-7-5-6-8-16(14)25-17/h5-10,12H,3-4,11H2,1-2H3,(H2,20,21,24)
InChI key
UGYXUEPBYOKNOL-UHFFFAOYSA-N
Biochem/physiol Actions
SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) that activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscle, avoiding PKA-dependent signaling.
potent and selective ligand of ABHD5 that activates ATGL by dissociating ABHD5 from PLIN1 and PLIN5
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable