SML2222
Carisbamate
≥98% (HPLC)
别名:
(S)-2-O-Carbamoyl-1-o-chlorophenyl-ethanol, JNJ-10234094, RWJ-333369, YKP 509, [(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
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关于此项目
经验公式（希尔记法）:
C9H10ClNO3
化学文摘社编号:
分子量:
215.63
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
form
powder
InChI
1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1
SMILES string
ClC1=C([C@H](O)COC(N)=O)C=CC=C1
InChI key
OLBWFRRUHYQABZ-MRVPVSSYSA-N
assay
≥98% (HPLC)
optical activity
[α]/D +77 to +87°, c = 0.2 in chloroform-d
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Antiepileptic; broad acute anticonvulsant, neuroprotective.
Carisbamate is an antiepileptic agent with broad anticonvulsant and neuroprotective activity. It has also been investigated as a possible treatment for alcohol dependence.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Erwin Z Mangubat et al.
Journal of neurosurgery, 122(6), 1283-1292 (2015-02-28)
The authors evaluated the preclinical feasibility of acutely stabilizing an active bihemispheric limbic epileptic circuit using closed-loop direct neurostimulation therapy in tandem with "on-demand'" convection-enhanced intracerebral delivery of the antiepileptic drug (AED) carisbamate. A rat model of electrically induced self-sustained
José Eduardo Marques-Carneiro et al.
Pharmaceuticals (Basel, Switzerland), 10(4) (2017-11-07)
The administration of lithium-pilocarpine (LiPilo) in adult rats is a validated model reproducing the main clinical and neuropathological features of temporal lobe epilepsy (TLE). Previous studies have shown that carisbamate (CRS) has the property of modifying epileptogenesis in this model.
Do Young Kim et al.
Epilepsia, 58(4), 617-626 (2017-02-24)
Carisbamate (CRS) is a novel monocarbamate compound that possesses antiseizure and neuroprotective properties. However, the mechanisms underlying these actions remain unclear. Here, we tested both direct and indirect effects of CRS on several cellular systems that regulate intracellular calcium concentration
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