SML2222
Carisbamate
≥98% (HPLC)
别名:
(S)-2-O-Carbamoyl-1-o-chlorophenyl-ethanol, JNJ-10234094, RWJ-333369, YKP 509, [(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +77 to +87°, c = 0.2 in chloroform-d
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
ClC1=C([C@H](O)COC(N)=O)C=CC=C1
InChI
1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1
InChI key
OLBWFRRUHYQABZ-MRVPVSSYSA-N
生化/生理作用
Antiepileptic; broad acute anticonvulsant, neuroprotective.
Carisbamate is an antiepileptic agent with broad anticonvulsant and neuroprotective activity. It has also been investigated as a possible treatment for alcohol dependence.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Do Young Kim et al.
Epilepsia, 58(4), 617-626 (2017-02-24)
Carisbamate (CRS) is a novel monocarbamate compound that possesses antiseizure and neuroprotective properties. However, the mechanisms underlying these actions remain unclear. Here, we tested both direct and indirect effects of CRS on several cellular systems that regulate intracellular calcium concentration
José Eduardo Marques-Carneiro et al.
Pharmaceuticals (Basel, Switzerland), 10(4) (2017-11-07)
The administration of lithium-pilocarpine (LiPilo) in adult rats is a validated model reproducing the main clinical and neuropathological features of temporal lobe epilepsy (TLE). Previous studies have shown that carisbamate (CRS) has the property of modifying epileptogenesis in this model.
Erwin Z Mangubat et al.
Journal of neurosurgery, 122(6), 1283-1292 (2015-02-28)
The authors evaluated the preclinical feasibility of acutely stabilizing an active bihemispheric limbic epileptic circuit using closed-loop direct neurostimulation therapy in tandem with "on-demand'" convection-enhanced intracerebral delivery of the antiepileptic drug (AED) carisbamate. A rat model of electrically induced self-sustained
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持