SML2236
L-012 钠盐
≥98% (HPLC), powder, neurotoxin
别名:
8-氨基-5-氯-2,3-二氢-7-苯基吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, 8-氨基-5-氯-7-苯基-2,3-二氢吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, L012
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关于此项目
经验公式（希尔记法）:
C13H8ClN4O2 · Na
化学文摘社编号:
分子量:
310.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
L-012 钠盐, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[Na+].Clc1nc(c(c3c1c(n[nH][c]3=O)[O-])N)c2ccccc2
InChI
1S/C13H9ClN4O2.Na/c14-11-8-7(12(19)17-18-13(8)20)9(15)10(16-11)6-4-2-1-3-5-6;/h1-5H,15H2,(H,17,19)(H,18,20);/q;+1/p-1
InChI key
IGEUYSJHQQCEFP-UHFFFAOYSA-M
相关类别
Application
L-012已被用作生物发光检测的探针，用于测定分离的小鼠肺中的活性氧（ROS）水平。
Biochem/physiol Actions
L-012是鲁米诺类似物，是培养物和动物体内广泛使用的活性氧和氮物质（RONS；ROS & RNS）化学发光（CL）探针。L-012显示出比鲁米诺、光泽精和MCLA显着更高的CL产量和灵敏度。L-012（LumH2）不是直接与超氧阴离子（O2−）反应，而是通过单电子氧化（在H2O2存在下由过氧化物酶催化）转化为LumH·自由基形式，然后与氧气（O2）反应生成O2−和L-012醌（q-Lum）。O2−依次与LumH·自由基反应，最终导致内过氧化物分解以发出发光。在较小的范围内，H2O2也可以与q-Lum反应产生发光。尽管对NADPH氧化酶衍生的RONS不是特异性的，但L-012也通常用于筛选NADPH氧化酶抑制剂。
在培养物和动物体内中广泛使用的活性氧和氮物种（RONS；ROS和RNS）化学发光（CL）探针。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Y Nishinaka et al.
Biochemical and biophysical research communications, 193(2), 554-559 (1993-06-15)
A sensitive chemiluminescence method for measuring the production of superoxide anion (O2-) by activated EoL-1 cells (human eosinophilic leukemia cell line) is described. Recently, we succeeded in synthesizing a new chemiluminescence probe, 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione (L-012). In the presence of L-012, activated
Muthusaravanan Sivaramakrishnan et al.
Current protocols, 3(8), e869-e869 (2023-08-25)
The reactive oxygen species (ROS) burst assay is a valuable tool for studying pattern-triggered immunity (PTI) in plants. During PTI, the interaction between pathogen recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs) leads to the rapid production of ROS in
Peishan Li et al.
Nature communications, 11(1), 4387-4387 (2020-09-03)
The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have been reported. In this study, using mouse models of breast cancer, we demonstrate that the
Jacek Zielonka et al.
Free radical biology & medicine, 65, 1310-1314 (2013-10-02)
L-012, a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2(*-)) and identify Nox inhibitors. Yet understanding of the free radical chemistry of the L-012 probe is still lacking. We
Andreas Daiber et al.
Redox biology, 12, 35-49 (2017-02-18)
Reactive oxygen and nitrogen species (RONS such as H2O2, nitric oxide) confer redox regulation of essential cellular functions (e.g. differentiation, proliferation, migration, apoptosis), initiate and catalyze adaptive stress responses. In contrast, excessive formation of RONS caused by impaired break-down by
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML2236-25MG | 04061835360451 |
| SML2236-5MG | 04061835360468 |
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