SML2236
L-012 钠盐
≥98% (HPLC), powder, neurotoxin
别名:
8-氨基-5-氯-2,3-二氢-7-苯基吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, 8-氨基-5-氯-7-苯基-2,3-二氢吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, L012
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关于此项目
经验公式（希尔记法）:
C13H8ClN4O2 · Na
化学文摘社编号:
分子量:
310.67
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
产品名称
L-012 钠盐, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
颜色
yellow to orange
溶解性
H2O: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
[Na+].Clc1nc(c(c3c1c(n[nH][c]3=O)[O-])N)c2ccccc2
InChI
1S/C13H9ClN4O2.Na/c14-11-8-7(12(19)17-18-13(8)20)9(15)10(16-11)6-4-2-1-3-5-6;/h1-5H,15H2,(H,17,19)(H,18,20);/q;+1/p-1
InChI key
IGEUYSJHQQCEFP-UHFFFAOYSA-M
相关类别
应用
L-012已被用作生物发光检测的探针，用于测定分离的小鼠肺中的活性氧（ROS）水平。
生化/生理作用
L-012是鲁米诺类似物，是培养物和动物体内广泛使用的活性氧和氮物质（RONS；ROS & RNS）化学发光（CL）探针。L-012显示出比鲁米诺、光泽精和MCLA显着更高的CL产量和灵敏度。L-012（LumH2）不是直接与超氧阴离子（O2−）反应，而是通过单电子氧化（在H2O2存在下由过氧化物酶催化）转化为LumH·自由基形式，然后与氧气（O2）反应生成O2−和L-012醌（q-Lum）。O2−依次与LumH·自由基反应，最终导致内过氧化物分解以发出发光。在较小的范围内，H2O2也可以与q-Lum反应产生发光。尽管对NADPH氧化酶衍生的RONS不是特异性的，但L-012也通常用于筛选NADPH氧化酶抑制剂。
在培养物和动物体内中广泛使用的活性氧和氮物种（RONS；ROS和RNS）化学发光（CL）探针。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Y Nishinaka et al.
Biochemical and biophysical research communications, 193(2), 554-559 (1993-06-15)
A sensitive chemiluminescence method for measuring the production of superoxide anion (O2-) by activated EoL-1 cells (human eosinophilic leukemia cell line) is described. Recently, we succeeded in synthesizing a new chemiluminescence probe, 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione (L-012). In the presence of L-012, activated
Peishan Li et al.
Nature communications, 11(1), 4387-4387 (2020-09-03)
The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have been reported. In this study, using mouse models of breast cancer, we demonstrate that the
Muthusaravanan Sivaramakrishnan et al.
Current protocols, 3(8), e869-e869 (2023-08-25)
The reactive oxygen species (ROS) burst assay is a valuable tool for studying pattern-triggered immunity (PTI) in plants. During PTI, the interaction between pathogen recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs) leads to the rapid production of ROS in
Julian Jehle et al.
Archives of medical science : AMS, 13(4), 930-936 (2017-07-20)
Multidrug resistance-associated protein 1 (MRP1) is an anion transporter which is implicated in the efflux of the intracellular antioxidant anion glutathione as well as leukotrienes. Pharmacological inhibition of MRP1 exhibits antioxidative and anti-atherosclerotic effects both in vitro and in vivo.
I Imada et al.
Analytical biochemistry, 271(1), 53-58 (1999-06-11)
Reactive oxygen species (ROS) play important roles in the defense mechanism against infection and in the pathogenesis of various diseases. Although chemical properties of ROS generated by leukocytes have been studied extensively, methods available for their analysis are not sufficiently
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