SML2236
L-012 钠盐
≥98% (HPLC), powder, neurotoxin
别名:
8-氨基-5-氯-2,3-二氢-7-苯基吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, 8-氨基-5-氯-7-苯基-2,3-二氢吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, L012
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关于此项目
经验公式（希尔记法）:
C13H8ClN4O2 · Na
化学文摘社编号:
分子量:
310.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
L-012 钠盐, ≥98% (HPLC)
SMILES string
[Na+].Clc1nc(c(c3c1c(n[nH][c]3=O)[O-])N)c2ccccc2
InChI
1S/C13H9ClN4O2.Na/c14-11-8-7(12(19)17-18-13(8)20)9(15)10(16-11)6-4-2-1-3-5-6;/h1-5H,15H2,(H,17,19)(H,18,20);/q;+1/p-1
InChI key
IGEUYSJHQQCEFP-UHFFFAOYSA-M
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
相关类别
Application
L-012已被用作生物发光检测的探针，用于测定分离的小鼠肺中的活性氧（ROS）水平。
Biochem/physiol Actions
L-012是鲁米诺类似物，是培养物和动物体内广泛使用的活性氧和氮物质（RONS；ROS & RNS）化学发光（CL）探针。L-012显示出比鲁米诺、光泽精和MCLA显着更高的CL产量和灵敏度。L-012（LumH2）不是直接与超氧阴离子（O2−）反应，而是通过单电子氧化（在H2O2存在下由过氧化物酶催化）转化为LumH·自由基形式，然后与氧气（O2）反应生成O2−和L-012醌（q-Lum）。O2−依次与LumH·自由基反应，最终导致内过氧化物分解以发出发光。在较小的范围内，H2O2也可以与q-Lum反应产生发光。尽管对NADPH氧化酶衍生的RONS不是特异性的，但L-012也通常用于筛选NADPH氧化酶抑制剂。
在培养物和动物体内中广泛使用的活性氧和氮物种（RONS；ROS和RNS）化学发光（CL）探针。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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