SML2239
INF39
≥98% (HPLC)
别名:
2-(2-氯苄基)丙烯酸乙酯, 2-氯-α-亚甲基-苯丙酸乙酯
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H13ClO2
化学文摘社编号:
分子量:
224.68
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
INF39, ≥98% (HPLC)
InChI
1S/C12H13ClO2/c1-3-15-12(14)9(2)8-10-6-4-5-7-11(10)13/h4-7H,2-3,8H2,1H3
InChI key
VTAOWWAFBSFWSG-UHFFFAOYSA-N
SMILES string
ClC1=C(CC(C(OCC)=O)=C)C=CC=C1
assay
≥98% (HPLC)
form
oil
color
colorless to light brown
storage temp.
−20°C
相关类别
Biochem/physiol Actions
INF39是一种口服活性丙烯酸酯衍生物以及无细胞毒性的INF4E类似物（在THP-1培养物中100 μM时无毒性，而INF4E在TC50 = 65 μM时无毒），它是针对NLRP3（含NACHT、LRR和PYD结构域蛋白3）ATP酶活性的一种不可逆抑制剂（100 μM INF39在15分钟内抑制52％；105 ng人类NLP3 & 250 μM ATP）对于NLRP3炎症小体组装和激活至关重要。INF39可有效降低培养中的鼠骨髓源性巨噬细胞中5 mM（30分钟）的ATP诱导的白介素1β（IL-1β）的释放和细胞焦亡（在对LPS引发的BMDM进行10 μM INF39的1小时处理后可分别降低55-58％和43-65％）并在2,4-二硝基苯磺酸（DNBS）诱导的结肠炎大鼠体内模型中减轻肠道相关的炎症（在0.2 mL橄榄油中12.5-50 mg/kg /天） 。
可抑制ATP依赖性巨噬细胞活化并减轻DNBS诱导的大鼠结肠炎的口服活性不可逆NLRP3抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Mattia Cocco et al.
Journal of medicinal chemistry, 60(9), 3656-3671 (2017-04-15)
Pharmacological inhibition of NLRP3 inflammasome activation may offer a new option in the treatment of inflammatory bowel disease. In this work, we report the design, synthesis, and biological screening of a series of acrylate derivatives as NLRP3 inhibitors. The in
Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors.
Mattia Cocco et al.
ChemMedChem, 11(16), 1790-1803 (2016-03-19)
NLRP3 inflammasome plays a key role in the intracellular activation of caspase-1, processing of pro-inflammatory interleukin-1β (IL-1β), and pyroptotic cell death cascade. The overactivation of NLRP3 is implicated in the pathogenesis of autoinflammatory diseases, known as cryopyrin-associated periodic syndromes (CAPS)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持