SML2243
BTSA1
≥98% (HPLC)
别名:
3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-thiazolyl)hydrazone]
方案
≥98% (HPLC)
表单
powder
颜色
red to dark red-brown
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
O=C1N(C2=NC(C3=CC=CC=C3)=CS2)N=C(C4=CC=CC=C4)/C1=N\NC5=NC=CS5
InChI key
KYVZVVOQWWCVPP-HKOYGPOVSA-N
生化/生理作用
BTSA1 is orally available, highly specific and potent BAX activator that binds to N-terminal activation site of Bax and induces conformational changes. BTSA1 potently induces apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
orally available, highly specific and potent BAX activator that binds to N-terminal activation site of Bax
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Denis E Reyna et al.
Cancer cell, 32(4), 490-505 (2017-10-11)
The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by suppressing BAX and its activators. We report the discovery of BTSA1, a pharmacologically optimized BAX
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