SML2243
BTSA1
≥98% (HPLC)
别名:
3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-thiazolyl)hydrazone]
InChI key
KYVZVVOQWWCVPP-HKOYGPOVSA-N
SMILES string
O=C1N(C2=NC(C3=CC=CC=C3)=CS2)N=C(C4=CC=CC=C4)/C1=N\NC5=NC=CS5
assay
≥98% (HPLC)
form
powder
color
red to dark red-brown
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
BTSA1 is orally available, highly specific and potent BAX activator that binds to N-terminal activation site of Bax and induces conformational changes. BTSA1 potently induces apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
orally available, highly specific and potent BAX activator that binds to N-terminal activation site of Bax
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Denis E Reyna et al.
Cancer cell, 32(4), 490-505 (2017-10-11)
The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by suppressing BAX and its activators. We report the discovery of BTSA1, a pharmacologically optimized BAX
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