SML2248
SK-216
≥98% (HPLC)
别名:
2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]-propanedioic acid sodium salt, SK 216, [5-[[6-[5-(1,1-dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]-propanedioic acid disodium salt
InChI
1S/C29H31NO6.2Na/c1-29(2,3)21-11-13-25-24(17-21)30-26(36-25)20-9-8-19-16-22(12-10-18(19)15-20)35-14-6-4-5-7-23(27(31)32)28(33)34;;/h8-13,15-17,23H,4-7,14H2,1-3H3,(H,31,32)(H,33,34);;/q;2*+1/p-2
InChI key
YYTGMMYYLGKWIK-UHFFFAOYSA-L
SMILES string
CC(C)(C)C(C=C1)=CC2=C1OC(C3=CC=C4C(C=CC(OCCCCCC(C([O-])=O)C([O-])=O)=C4)=C3)=N2.[2Na+]
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 0.5 mg/mL, clear (warmed)
storage temp.
room temp
Biochem/physiol Actions
SK-216 is an orally active potent and selective inhibitor of Plasminogen activator inhibitor-1 (PAI-1) that inhibits tumor progression and angiogenesis. SK-216 inhibits migration and tube formation of cultured human umbilical vein endothelial cells induced by various angiogenic factors. SK-116 prevents a formation of gastro-intestinal polyps in Min mice.
orally active potent and selective inhibitor of Plasminogen activator inhibitor-1 (PAI-1)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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