SML2254
J-113397
≥98% (HPLC)
别名:
1-[(3R,4R)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
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关于此项目
经验公式（希尔记法）:
C24H37N3O2
化学文摘社编号:
分子量:
399.57
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
J-113397, ≥98% (HPLC)
InChI
1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
SMILES string
CCN1C2=CC=CC=C2N([C@H]3[C@H](CO)CN(CC4CCCCCCC4)CC3)C1=O
InChI key
MBGVUMXBUGIIBQ-LEWJYISDSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +7 to +10°, c = 1 in isopropanol
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
Biochem/physiol Actions
Antagonist of NOP, the nociceptin/orphanin FQ (N/OFQ) receptor.
J-113397 is an antagonist of NOP, the nociceptin/orphanin FQ (N/OFQ) receptor. J-113397 exhibited an IC50 value of 2.3 nM in Chinese hamster ovary (CHO) cells expressing ORL1 receptor showed with 600-fold or less affinity for μ-, δ- and κ-opioid receptors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Klaus Linz et al.
Anesthesiology, 126(4), 708-715 (2017-03-16)
Cebranopadol is a first-in-class analgesic with agonist activity at classic opioid peptide receptors and the nociceptin/orphanin FQ peptide receptor. The authors compared the antinociceptive and respiratory depressant effects of cebranopadol and the classic opioid fentanyl and used selective antagonists to
Raymond F Genovese et al.
Behavioural pharmacology, 28(7), 521-530 (2017-07-14)
The nociceptin/orphanin FQ peptide (NOP) receptor is believed to have an integral modulatory function in the stress response system. We evaluated the highly selective NOP antagonist J-113397 (7.5 and 20.0 mg/kg), using a predator exposure in which rats were exposed to
S Ozaki et al.
European journal of pharmacology, 387(3), R17-R18 (2000-01-29)
We discovered a potent nociceptin/orphanin FQ receptor (ORL1) receptor antagonist, J-113397 (1-[(3R, 4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one). J-113397 inhibited [125I][Tyr(14)]nociceptin binding to Chinese hamster ovary (CHO) cells expressing ORL1 receptor in a dose-dependent manner (IC(50); 2. 3 nM), but showed 600-fold or less
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