方案
≥98% (HPLC)
表单
powder
颜色
off-white to brown
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O
InChI key
LDPDVNYCIOHPGF-UHFFFAOYSA-N
相关类别
生化/生理作用
GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.
Selective allosteric inhibitor of PARP14 macrodomain 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Marion Schuller et al.
ACS chemical biology, 12(11), 2866-2874 (2017-10-11)
Macrodomains are conserved protein interaction modules that can be found in all domains of life including in certain viruses. Macrodomains mediate recognition of sequence motifs harboring adenosine diphosphate ribose (ADPR) modifications, thereby regulating a variety of cellular processes. Due to
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持