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Merck
CN

SML2287

泊沙康唑标准液

≥98% (HPLC), lanosterol 14α-demethylase inhibitor, powder

别名:

泊沙康唑标准液 溶液, 2,5-脱水-1,3,4-丁氧基-2-C-(2,4-二氟苯基)-4-[[4-[4-[4-[1-[(1S,2S)-1-]乙基-2-羟丙基] -1,5-二氢-5-氧代-4H-1,2,4-三唑-4-基]苯基] -1-哌嗪基]苯氧基]甲基] -1-(1H-1, 2,4-三唑-1-基)-D-苏糖醇, Sch 56592

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关于此项目

经验公式（希尔记法）:
C37H42F2N8O4
化学文摘社编号:
171228-49-2
分子量:
700.78
MDL编号:
MFCD00941162
UNSPSC代码:
12352200
NACRES:
NA.77

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产品名称

泊沙康唑标准液, ≥98% (HPLC)

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D -24 to -32°, c = 1.0 in chloroform-d

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

SMILES字符串

Fc1c(ccc(c1)F)[C@@]3(OC[C@H](C3)COc4ccc(cc4)N5CCN(CC5)c6ccc(cc6)N7C=NN(C7=O)[C@H]([C@@H](O)C)CC)C[n]2ncnc2

InChI

1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1

InChI key

RAGOYPUPXAKGKH-XAKZXMRKSA-N

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相关类别

应用

泊沙康唑用于：
  • 土曲霉抗真菌药敏试验
  • 作为羊毛甾醇14α-脱甲基酶 (CYP51) 特异性抑制剂，研究其对白色念珠菌细胞膜通透性的影响
  • 研究其对前鞭毛体的影响

生化/生理作用

泊沙康唑是一种高效的广谱抗真菌剂，可抑制念珠菌引起的酵母菌感染。它通过抑制羊毛甾醇14α-脱甲基酶 (CYP51)阻断真菌生长。与其他抗真菌唑类药物相反，泊沙康唑据报道不会诱导外排泵机制。泊沙康唑对各类南美锥虫病的病原体克氏锥虫菌株具有抑制作用。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000486711
0000486711
0000479544
0000479543
0000445000

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