SML2299
Photoregulin3
≥98% (HPLC)
别名:
2-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-6,7-dimethoxy-4(3H)-quinazolinone, PR3
InChI
1S/C22H23N3O3/c1-27-19-12-17-18(13-20(19)28-2)23-21(24-22(17)26)14-25-10-8-16(9-11-25)15-6-4-3-5-7-15/h3-8,12-13H,9-11,14H2,1-2H3,(H,23,24,26)
InChI key
CKCSOMMBIPJYSG-UHFFFAOYSA-N
SMILES string
OC(C1=C2)=NC(CN3CCC(C4=CC=CC=C4)=CC3)=NC1=CC(OC)=C2OC
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
Nr2e3 modulator
Photoregulin3 is a modulator of the rod transcription factor Nr2e3 that inhibits rod photoreceptor gene expression. Photoregulin3 significantly rescues photoreceptor in RhoP23H mice.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Navickas, et al.
Nature Cell Biology (2023)
Paul A Nakamura et al.
eLife, 6 (2017-11-18)
Regulation of rod gene expression has emerged as a potential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP). We previously reported on a small molecule modulator of the rod transcription factor Nr2e3, Photoregulin1 (PR1), that regulates the
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