SML2301
EpoY
≥97% (HPLC), Vasohibin/SVBP inhibitor, powder
别名:
(2S,3S)-3-[[[(1S)-1-Carboxy-2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-2-oxiranecarboxylic acid 2-ethyl ester, (S)-2-((2S,3S)-3-(ethoxycarbonyl) oxirane -2-carboxamido)-3-(4-hydroxyphenyl) propanoic acid, SD-142
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关于此项目
Assay:
≥97% (HPLC)
Form:
powder
产品名称
EpoY, ≥97% (HPLC)
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)[C@H]2O[C@@H]2C(OCC)=O
InChI
1S/C15H17NO7/c1-2-22-15(21)12-11(23-12)13(18)16-10(14(19)20)7-8-3-5-9(17)6-4-8/h3-6,10-12,17H,2,7H2,1H3,(H,16,18)(H,19,20)/t10-,11-,12-/m0/s1
InChI key
PSLWNPKMALERSK-SRVKXCTJSA-N
Biochem/physiol Actions
EpoY is an irreversible inhibitor of the major brain tubulin tyrosine carboxypeptidase (TCP), shown to be a complex of vasohibin-1 (VASH1) with the small vasohibin binding protein (SVBP). Reversible detyrosination of alpha-tubulin is vital to microtubule dynamics and functions including regulation of neuron differentiation, and defects in the detryosination have also been been associated with cancer and cardiomyopathies EpoY inhibited TCP activity with an IC50 value around 500 nM. It reduced detyrosinated a-tubulin levels and caused severe differentiation defects.
Inhibitor of Vasohibin/SVBP, a tubulin tyrosine carboxypeptidase (TCP) that regulates neuron differentiation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable