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Merck
CN

SML2301

EpoY

≥97% (HPLC), Vasohibin/SVBP inhibitor, powder

别名:

(2S,3S)-3-[[[(1S)-1-Carboxy-2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-2-oxiranecarboxylic acid 2-ethyl ester, (S)-2-((2S,3S)-3-(ethoxycarbonyl) oxirane -2-carboxamido)-3-(4-hydroxyphenyl) propanoic acid, SD-142

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关于此项目

经验公式（希尔记法）:
C15H17NO7
化学文摘社编号:
245660-13-3
分子量:
323.30
UNSPSC Code:
12352200
NACRES:
NA.21

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产品名称

EpoY, ≥97% (HPLC)

InChI

1S/C15H17NO7/c1-2-22-15(21)12-11(23-12)13(18)16-10(14(19)20)7-8-3-5-9(17)6-4-8/h3-6,10-12,17H,2,7H2,1H3,(H,16,18)(H,19,20)/t10-,11-,12-/m0/s1

InChI key

PSLWNPKMALERSK-SRVKXCTJSA-N

SMILES string

O=C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)[C@H]2O[C@@H]2C(OCC)=O

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

相关类别

Biochem/physiol Actions

EpoY is an irreversible inhibitor of the major brain tubulin tyrosine carboxypeptidase (TCP), shown to be a complex of vasohibin-1 (VASH1) with the small vasohibin binding protein (SVBP). Reversible detyrosination of alpha-tubulin is vital to microtubule dynamics and functions including regulation of neuron differentiation, and defects in the detryosination have also been been associated with cancer and cardiomyopathies EpoY inhibited TCP activity with an IC50 value around 500 nM. It reduced detyrosinated a-tubulin levels and caused severe differentiation defects.
Inhibitor of Vasohibin/SVBP, a tubulin tyrosine carboxypeptidase (TCP) that regulates neuron differentiation.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000409720
0000409721
0000409721
0000409720
0000320985

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Chrystelle Aillaud et al.
Science (New York, N.Y.), 358(6369), 1448-1453 (2017-11-18)
Reversible detyrosination of α-tubulin is crucial to microtubule dynamics and functions, and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. The identity of the tubulin tyrosine carboxypeptidase (TCP) responsible for detyrosination has remained unclear. We used chemical proteomics

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Irreversible Inhibitors

Discover definitions and uses for irreversible inhibitors including the types of irreversible inhibitors: suicide inhibitors, heavy metal inhibitors, and time-dependent inhibitors.

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