SML2304
盐酸氯氮平N-氧化物
≥98% (HPLC), powder, muscarinic DREADD activator
别名:
盐酸氯氮平N-氧化物, 8-氯-11-（4-甲基-1-哌嗪基）-5H-二苯并[b,e]（1,4）二氮杂N-氧化物, 盐酸盐
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关于此项目
经验公式（希尔记法）:
C18H19ClN4O · xHCl
化学文摘社编号:
分子量:
342.82 (free base basis)
UNSPSC Code:
12352119
NACRES:
NA.77
产品名称
盐酸氯氮平N-氧化物, ≥98% (HPLC), Water soluble Clozapine N-oxide
SMILES string
ClC1=CC2=C(NC(C=CC=C3)=C3C(N4CC[N+]([O-])(C)CC4)=N2)C=C1.[xHCl]
InChI
1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key
OGUCZBIQSYYWEF-UHFFFAOYSA-N
biological source
synthetic
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
solubility
DMSO: 40 mg/mL
water: 40 mg/mL
shipped in
ambient
storage temp.
2-8°C
相关类别
General description
氯氮平n -氧化物盐酸盐是氯氮平n -氧化物(CNO)的一种水溶性形式(Sigma cat# C0832)。CNO是非典型抗精神病药物氯氮平的一种惰性代谢产物。CNO是设计药物特异激活的化学遗传设计受体(DREADD)中工程Gq蛋白偶联受体(GPCR)配体。DREADD的典型应用是测试，增强神经元和非神经元细胞的神经元放电和激活Gq信号。
通过使用细胞类型特异性启动子驱动DREADD表达可以实现对细胞群体的选择性靶向，并通过重组系统进一步控制该启动子的表达。DREADD对内源性配体的亲和力较低，其组成活性较低，但可能被CNO等合成化合物激活。
低nM浓度的CNO激活了DREADD系统，并调动了细胞内钙。当小鼠和大鼠按推荐剂量（一般为0.1-3 mg/kg）给药时，CNO在药理学和行为学上似乎是惰性的。CNO通常通过注射给药，但也可以混合到食物或饮用水中。
通过使用细胞类型特异性启动子驱动DREADD表达可以实现对细胞群体的选择性靶向，并通过重组系统进一步控制该启动子的表达。DREADD对内源性配体的亲和力较低，其组成活性较低，但可能被CNO等合成化合物激活。
低nM浓度的CNO激活了DREADD系统，并调动了细胞内钙。当小鼠和大鼠按推荐剂量（一般为0.1-3 mg/kg）给药时，CNO在药理学和行为学上似乎是惰性的。CNO通常通过注射给药，但也可以混合到食物或饮用水中。
Other Notes
这不是药用级别的产品。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Masaki Ishikawa et al.
The FEBS journal, 291(5), 945-964 (2023-12-01)
Indoleamine 2,3-dioxygenase 2 (IDO2) is an enzyme of the tryptophan-kynurenine pathway that is constitutively expressed in the brain. To provide insight into the physiological role of IDO2 in the brain, behavioral and neurochemical analyses in IDO2 knockout (KO) mice were
Susan M Ferguson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(28), 11668-11676 (2013-07-12)
The dorsal striatum has been implicated in reward-based decision making, but the role played by specific striatal circuits in these processes is essentially unknown. Using cell phenotype-specific viral vectors to express engineered G-protein-coupled DREADD (designer receptors exclusively activated by designer
Hu Zhu et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1880-1892 (2014-02-15)
Synaptic consolidation is a process thought to consolidate memory in the brain. Although lesion studies have mainly implicated the hippocampus (HPC) in this process, it is unknown which cell type(s) or regions of the HPC might be essential for synaptic
Daniel J Urban et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(5), 1404-1415 (2015-09-19)
Elucidating how the brain's serotonergic network mediates diverse behavioral actions over both relatively short (minutes-hours) and long period of time (days-weeks) remains a major challenge for neuroscience. Our relative ignorance is largely due to the lack of technologies with robustness
Blaine N Armbruster et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(12), 5163-5168 (2007-03-16)
We evolved muscarinic receptors in yeast to generate a family of G protein-coupled receptors (GPCRs) that are activated solely by a pharmacologically inert drug-like and bioavailable compound (clozapine-N-oxide). Subsequent screening in human cell lines facilitated the creation of a family
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