SML2309

Oxaphenamide

Name: Oxaphenamide
Brand: SIGMA

≥98% (HPLC)

别名:

2-Hydroxy-N-(4-hydroxyphenyl)benzamide, 4′-Hydroxysalicylanilide, Osalmide, Oxaphenamide, p-hydroxyphenylsalicylamide

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₁NO₃

化学文摘社编号:

526-18-1

分子量:

229.23

UNSPSC Code:

12352200

NACRES:

NA.77

EC Number:

208-385-9

MDL number:

MFCD00020026

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SMILES string

N(c2ccc(cc2)O)C(=O)c1c(cccc1)O

InChI key

LGCMKPRGGJRYGM-UHFFFAOYSA-N

InChI

1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.

potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis; choleretic agent