SML2310
Thiodigalactoside
≥98% (HPLC)
别名:
Thiodigalactoside, β-D-Galactopyranosyl 1-thio-β-D-galactopyranoside, D-Galactopyranosylthio-β-D-galactopyranoside, TDG, D-Galactopyranosyl-β-D-thiogalactopyranoside
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关于此项目
经验公式（希尔记法）:
C12H22O10S
化学文摘社编号:
分子量:
358.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Thiodigalactoside, ≥98% (HPLC)
SMILES string
S([C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)C1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CO
InChI
1S/C12H22O10S/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8+,9-,10-,11+,12?/m1/s1
InChI key
SYKYBMOFPMXDRQ-VVLLKYQZSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
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Biochem/physiol Actions
Thiodigalactoside (TDG)is a potent inhibitor of galectin-1 (GAL1) that suppress tumor growth by inhibiting multiple cancer enhancing activities of galectin-1, including immune cell dysregulation, angiogenesis and protection against oxidative stress. Thiodigalactoside reverses galectin-1-induced cisplatin resistance in HCC cells. Thiodigalactoside significantly reduces body weight gain in diet-induced obese rats.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
S Aggarwal et al.
Oral diseases, 22(5), 445-453 (2016-03-24)
Thiodigalactoside (TDG), a synthetic inhibitor of β-galactoside-binding protein (β-GBP) suppresses tumour growth by inhibiting multiple cancer enhancing activities of β-GBP. Hence, we attempted to understand whether disruption of β-GBP functions and indirect inhibition of Treg cells by TDG affect the
Yu-Chi Su et al.
PloS one, 11(2), e0148408-e0148408 (2016-02-10)
Hepatocellular carcinoma (HCC) is one of the most common cancers in Taiwan. Although chemotherapy is the primary treatment for HCC patients, drug resistance often leads to clinical failure. Galectin-1 is a beta-galactoside binding lectin which is up-regulated in HCC patients
Isabel Pablos et al.
Cell reports, 37(4), 109892-109892 (2021-10-22)
The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics. We identify more than 100 substrates in human lung and kidney cells supported by analyses of SARS-CoV-2-infected
Hilal Ahmad Parray et al.
International journal of molecular sciences, 16(7), 14441-14463 (2015-06-30)
Previously, galectin-1 (GAL1) was found to be up-regulated in obesity-prone subjects, suggesting that use of a GAL1 inhibitor could be a novel therapeutic approach for treatment of obesity. We evaluated thiodigalactoside (TDG) as a potent inhibitor of GAL1 and identified
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