SML2337
Diasarone-I
≥98% (HPLC)
别名:
(E)-3-ethyl-2-methyl-3-(2′′,4′′,5′′-trimethoxy)phenyl-1-(2′,4′,5′-trimethoxy)phenyl-1-propene, 1,1′-[(1E)-3-Ethyl-2-methyl-1-propene-1,3-diyl]bis[2,4,5-trimethoxybenzene], Diasarone 1, Diasarone I, NEOLASA-I
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
C/C(C(CC)C1=CC(OC)=C(OC)C=C1OC)=C\C2=C(OC)C=C(OC)C(OC)=C2
InChI
1S/C24H32O6/c1-9-17(18-12-22(28-6)24(30-8)14-20(18)26-4)15(2)10-16-11-21(27-5)23(29-7)13-19(16)25-3/h10-14,17H,9H2,1-8H3/b15-10+
InChI key
GGIJVVURVQQPBB-XNTDXEJSSA-N
Biochem/physiol Actions
The antiviral effect of Diasarone-I includes half maximal effective concentration (EC50) of 4.5 μM and half maximal cytotoxicity concentration (CC50) of >80 μM.
Diasarone-I is an antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection. Diasarone-I is binds to the viral 2′O methyltransferase of nonstructural protein 5 (NS5). It also decreases the DENV2-induced STAT1 phosphorylation and IFN-stimulated genes (ISGs) expression.
antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable