assay
≥98% (HPLC)
form
powder
color
white to very dark gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
potent USP1 inhibitor that induces ID1 degradation, upregulation of p21 and cytoxicity in K562 and other leukemic cell lines
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Helena Mistry et al.
Molecular cancer therapeutics, 12(12), 2651-2662 (2013-10-17)
Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the ID1 protein has not yet been therapeutically targeted in leukemia. ID1 is normally polyubiquitinated and degraded by
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