SML2372
β-Muricholic Acid
≥98% (HPLC), farnesoid X receptor antagonist, powder
别名:
β-MCA, (3a,5b,6b,7b)-3,6,7-trihydroxy-cholan-24-oic acid, 5β-Cholanic acid-3α,6β,7β-triol, beta-Muricholic Acid
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关于此项目
经验公式（希尔记法）:
C24H40O5
化学文摘社编号:
分子量:
408.57
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
β-Muricholic Acid, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +59 to +65°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O[C@H]1[C@H]2[C@@](C3C([C@H]1O)C4[C@@](C(CC4)C(CCC(=O)O)C)(CC3)C)(CC[C@H](C2)O)C
InChI
1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13?,14-,15?,16?,17?,18+,20?,21+,22-,23-,24-/m1/s1
InChI key
DKPMWHFRUGMUKF-CWNVCPLQSA-N
Application
β-Muricholic Acid has been used as a bile acid to study its effects on the expression of pluripotency, stemness, and inflammatory genes in primary mouse hepatocytes (PMH) and tumor-initiating stem-like cells(TICs). It has also been used as a bile acid to study its effects on gut transit ingnotobiotic or conventional mouse models.
Biochem/physiol Actions
β-Muricholic Acid is a naturally occurring trihydroxy hydrophilic bile acid that is produced in the liver of murine. It serves as a biliary cholesterol-desaturating agent and aids in the dissolution of cholesterol gallstones.
β-Muricholic acid (β-MCA) is a natural murine-specific bile acid. β-Muricholic acid has been shown to reduce the absorption of cholesterol. It also has some activity as a farnesoid X receptor antagonist.
Murine-specific bile acid, farnesoid X receptor antagonist
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable