SML2377
GSK′962
≥98% (HPLC)
别名:
1-[(5R)-4,5-Dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-1-propanone; 2,2-Dimethyl-1-(5(R)-phenyl-4,5-dihydro-pyrazol-1-yl)-propan-1-one, GSK 962, GSK 963 inactive control, GSK 963 negative control, GSK′ 962A, GSK′962A, GSK′963 inactive control, GSK′963 negative control, GSK-962, GSK-962A, GSK962, GSK962A
产品名称
GSK′962, ≥98% (HPLC)
SMILES string
O=C(C(C)(C)C)N1[C@@H](C2=CC=CC=C2)CC=N1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
GSK′962 (GSK′962A) corresponds to the inactive (R)-enantiomer of the highly potent and selective RIPK1 (RIP1) inhibitor GSK′963 (GSK′963A). GSK′962 serves as an ideal GSK′963 negative control compound for probing RIPK1-mediated responses both in vitro and in vivo.
Inactive (R)-enantiomer and an ideal negative control of GSK′963 for probing RIPK1-mediated responses both in vitro and in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Dan Weng et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(20), 7391-7396 (2014-05-07)
A number of pathogens cause host cell death upon infection, and Yersinia pestis, infamous for its role in large pandemics such as the "Black Death" in medieval Europe, induces considerable cytotoxicity. The rapid killing of macrophages induced by Y. pestis
Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase.
S B Berger et al.
Cell death discovery, 1, 15009-15009 (2015-01-01)
Necroptosis and signaling regulated by RIP1 kinase activity is emerging as a key driver of inflammation in a variety of disease settings. A significant amount has been learned about how RIP1 regulates necrotic cell death through the use of the
Nivea Farias Luz et al.
Journal of immunology (Baltimore, Md. : 1950), 196(12), 5056-5063 (2016-05-18)
Leishmaniasis is an important parasitic disease found in the tropics and subtropics. Cutaneous and visceral leishmaniasis affect an estimated 1.5 million people worldwide. Despite its human health relevance, relatively little is known about the cell death pathways that control Leishmania
Mallary C Greenlee-Wacker et al.
Blood, 129(24), 3237-3244 (2017-05-06)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causes infections associated with extensive tissue damage and necrosis. In vitro, human neutrophils fed CA-MRSA lyse by an unknown mechanism that is inhibited by necrostatin-1, an allosteric inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK-1). RIPK-1
Wenjing Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(7), E1475-E1484 (2018-02-01)
Tubular cell necrosis is a key histological feature of acute kidney injury (AKI). Necroptosis is a type of programed necrosis, which is executed by mixed lineage kinase domain-like protein (MLKL) upon its binding to the plasma membrane. Emerging evidence indicates
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