SML2385
Andrastin A
≥95% (HPLC)
别名:
(3β,5β,8α,9β,10α,13α)-3β-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylic acid methyl ester
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关于此项目
经验公式（希尔记法）:
C28H38O7
化学文摘社编号:
分子量:
486.60
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
Assay:
≥95% (HPLC)
Form:
powder
assay
≥95% (HPLC)
form
powder
color
white to beige
storage temp.
−20°C
SMILES string
O(C1C(C2[C@@]([C@@H]3C(C4([C@](C(=C3)C)(C(=O)C(C4=O)C)C)C(=O)OC)(CC2)C)(CC1)C=O)(C)C)C(=O)C
InChI
1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,16,18-20H,9-12H2,1-8H3/t16?,18?,19-,20?,25?,26+,27+,28?/m0/s1
InChI key
GRBXNADBNJGZRK-BCMOVVIDSA-N
Biochem/physiol Actions
Andrastin A is a meroterpenoid protein farnesyltransferase inhibitor with anticancer activity. It has been shown to inhibit the farnesyltransferase activity of the oncogenic Ras proteins and inhibit the efflux of anticancer drugs from multidrug-resistant cancer cells.
Farnesyltransferase inhibitor with anticancer activity; mycotoxin
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable