SML2388
SW157765
≥98% (HPLC)
别名:
3-(2-Furanyl)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-2-propenamide
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关于此项目
经验公式（希尔记法）:
C19H13N3O3
化学文摘社编号:
分子量:
331.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
N(c2cc3nc([o]c3cc2)c4ccncc4)C(=O)\C=C\c1[o]ccc1
InChI
1S/C19H13N3O3/c23-18(6-4-15-2-1-11-24-15)21-14-3-5-17-16(12-14)22-19(25-17)13-7-9-20-10-8-13/h1-12H,(H,21,23)/b6-4+
InChI key
QSSYRORXXFTVFI-GQCTYLIASA-N
assay
≥98% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
SW157765 is a selective inhibitor of the non-canonical glucose transporter GLUT8 (SLC2A8), which exhibit potent anticancer activity on KRAS/KEAP1 mutant NSCLC cells that selectively depend on GLUT8 for glucose intake to support serine biosynthesis.
selective inhibitor of the non-canonical glucose transporter GLUT8 (SLC2A8)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Elizabeth A McMillan et al.
Cell, 173(4), 864-878 (2018-04-24)
Diversity in the genetic lesions that cause cancer is extreme. In consequence, a pressing challenge is the development of drugs that target patient-specific disease mechanisms. To address this challenge, we employed a chemistry-first discovery paradigm for de novo identification of
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