SML2399
ML327
≥98% (HPLC)
别名:
1,2-Dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-3-pyridinecarboxamide, CID 60167648
登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C19H18N4O4
化学文摘社编号:
分子量:
366.37
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[nH]1[c](c(ccc1)C(=O)NCCCNC(=O)c2n[o]c(c2)c3ccccc3)=O
InChI key
NNNDNXLMQAPQQQ-UHFFFAOYSA-N
Biochem/physiol Actions
regulator of E-cadherin transcription that restores E-cadherin expression in cancer cell lines; inducer of mesenchymal-to-epithelial transition (MET)
ML327 is a regulator of E-cadherin transcription that restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable