SML2409
NITD008
≥98% (HPLC), falviviruses inhibitor, powder
别名:
7-(2-C-Ethynyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 7-Deaza-2′-C-acetylene-adenosine, NITD 008
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关于此项目
经验公式（希尔记法）:
C13H14N4O4
化学文摘社编号:
分子量:
290.27
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
NITD008, ≥98% (HPLC)
InChI
1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1
SMILES string
NC1=C2C=CN(C2=NC=N1)[C@@H]3O[C@@H]([C@H]([C@](C#C)3O)O)CO
InChI key
NKRAIOQPSBRMOV-NRMKKVEVSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
−20°C
Biochem/physiol Actions
NITD008 is a selective inhibitor of flaviviruses including dengue virus (EC50 = 0.64 μM), hepatitis C virus and Zika virus, and has also been shown to inhibit tick-borne flaviviruses in vitro. NITD008 has been reported to inhibit RNA-dependent RNA polymerase (RdRp), an essential protein of RNA viruses.
Selective inhibitor of flaviviruses including dengue virus, hepatitis C virus, and Zika virus
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Amjad Ali et al.
Asian Pacific journal of tropical medicine, 10(4), 321-331 (2017-05-30)
Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV
Michael K Lo et al.
Antiviral research, 130, 46-49 (2016-03-27)
There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study
Zheng Yin et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(48), 20435-20439 (2009-11-18)
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year. Neither a vaccine nor an antiviral therapy is currently
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