SML2422
槐果碱
≥95% (HPLC)
别名:
(-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC
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关于此项目
经验公式（希尔记法）:
C15H22N2O
化学文摘社编号:
分子量:
246.35
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
SMILES string
[Br-].N21[C@@H]3[C@@H]([C@@H]4N(C[C@@H]3CCC2)C(=O)C=CC4)CCC1.[H+]
InChI
1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1
InChI key
NBBQEIQEBNYSFK-PUILLJIJSA-N
biological source
Sophora alopecuroides
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D -26 to -35°, c = 0.5 in ethanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
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Biochem/physiol Actions
Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Genhuan Yang et al.
Annals of palliative medicine, 9(4), 1622-1630 (2020-06-13)
Cigarette smoking is one of the main predisposing factors for atherosclerosis, which can lead to vascular inflammation. Emerging research has demonstrated that the rate of restenosis is increased following angioplasty in smokers. Sophocarpine, one of the Sophora alkaloids, can play
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