SML2428
Pentabromopseudilin
≥97% (HPLC)
别名:
Pentabromopseudilin, 2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol, PBP
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关于此项目
Assay:
≥97% (HPLC)
Form:
solid
assay
≥97% (HPLC)
form
solid
storage temp.
−20°C
SMILES string
OC1=C(Br)C=C(Br)C=C1C2=C(Br)C(Br)=C(Br)N2
InChI
1S/C10H4Br5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H
InChI key
LXMNWKJHYOZUQL-UHFFFAOYSA-N
General description
Pentabromopseudilin (PBP) is a potent antibiotic originally isolated from the marine bacterium Pseudomonas bromoutilis. 2 PBP exhibits cytotoxic, antibacterial and phytotoxic activities, including the inhibition of human 12- and 15-lipoxygenases3 and potent inhibition of myosin-dependent processes. 4-5 PBP was identified as a potent inhibitor of the motor activity of vertebrate myosin V with an IC50 value of 1.2μM. 5 PBP inhibits the ATPase activity of myosin by increasing its affinity for ADP, reducing ATP-binding and hydrolysis rates, and through coupling between actin and nucleotide-binding sites in the motor domain. 4 Recently, it was also demonstrated that PBP suppresses TGF-β activity.
Other Notes
Solubility: Chloroform/dichloromethane (at least 10 mg/ml), methanol/ethanol (at least 1 mg/ml), DMSO (10mM)
Working Stock: PBP can be dissolved in DMSO at concentration of 10mM, solution should be stored in the dark at -80°C.
Working Stock: PBP can be dissolved in DMSO at concentration of 10mM, solution should be stored in the dark at -80°C.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable