SML2434
TP-238 Hydrochloride
≥98% (HPLC)
别名:
1-(3-(6-(4-(3-dimethylamino-propoxy)-phenyl)-2-methylsulfonyl-pyrimidin-4-ylamino)-propyl)-1H-pyrazole Hydrochloride, N-(3-(1H-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride
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关于此项目
经验公式（希尔记法）:
C22H30N6O3S · xHCl
分子量:
458.58 (free base basis)
UNSPSC代码:
51111800
NACRES:
NA.77
生化/生理作用
Chemical probe for CECR2/BPTF bromodomains
TP-238 is a chemical probe for CECR2 (cat eye syndrome chromosome region, candidate 2), a gene expressed in the nervous system involved in neurulation, and for BPTF bromodomains. It has an activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 showed an IC50 of 30nM against CECR2 and 350nM against BPTF in an alphascreen assay and a KD of 10nM for CECR2 and 120nM for BPTF by ITC. The structurally related negative control TP-422 is completely inactive against BPTF and CECR2.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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