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经验公式(希尔记法):
C25H25ClN2O4S
化学文摘社编号:
分子量:
485.00
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
GLPG0974, ≥98% (HPLC)
InChI
1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1
InChI key
MPMKMQHJHDHPBE-RUZDIDTESA-N
SMILES string
O=C(C1=CSC2=C1C=CC=C2)N3CC[C@]3(C)C(N(CC4=CC=CC(Cl)=C4)CCCC(O)=O)=O
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +175 to +200°, c = 1 in chloroform-d
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
相关类别
Biochem/physiol Actions
GLPG0974是一种口服,高亲和力,有效和选择性的游离脂肪酸受体2(FFA2;FFAR2;GPCR43;GPR43)拮抗剂(hFFA2 Kd=7.5 nM;IC50=9 nM;乙酸钠EC80诱导的HEK293 hFFA2中的Ca2+通量转染子)对包括FFA3(GPR41)在内的55种其他受体/通道/转运蛋白(IC50 >10 μM)几乎没有效力。GLPG0974抑制乙酸盐诱导的人嗜中性粒细胞迁移(IC50=27 nM),并表现出体内功效(0.1或1 mg/kg胃内)对抗NSAID消炎痛/FFA2激动剂苯乙酰胺-1共同治疗诱导的十二指肠病变,具有良好的药代动力学特性和口服可用性(大鼠F=47%;口服5 mg/kg)。
口服,高亲和力,有效和选择性的游离脂肪酸受体2(FFA2;FFAR2;GPCR43;GPR43)拮抗剂,具有体外和体内效力。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Microbiome, 11(1), 204-204 (2023-09-12)
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