SML2445
PKS21004
≥98% (HPLC)
别名:
(2S)-N1-[2-[([1,1′-biphenyl]-3-ylcarbonyl)amino]ethyl]-N4-(1,1-dimethylethyl)-2-[(1-oxo-3-phenylpropyl)amino]-butanediamide
InChI
1S/C32H38N4O4/c1-32(2,3)36-29(38)22-27(35-28(37)18-17-23-11-6-4-7-12-23)31(40)34-20-19-33-30(39)26-16-10-15-25(21-26)24-13-8-5-9-14-24/h4-16,21,27H,17-20,22H2,1-3H3,(H,33,39)(H,34,40)(H,35,37)(H,36,38)/t27-/m0/s1
InChI key
ZMFRLEFFYGXGES-MHZLTWQESA-N
SMILES string
O=C(N[C@@H](CC(NC(C)(C)C)=O)C(NCCNC(C1=CC=CC(C2=CC=CC=C2)=C1)=O)=O)CCC3=CC=CC=C3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
PKS21004 is highly selective, potent and reversible inhibitor of the Plasmodium falciparum proteasome (Pf20S) β5 subunit. It is not active against mammalian c-20S and i-20S proteasome subunits. PKS21004 is effective against erythrocytic, sexual, and liver-stage parasites. Also it is active against parasites resistant to current antimalarials, and strains from patients in Africa.
highly selective, potent and reversible inhibitor of the Plasmodium falciparum proteasome (Pf20S) β5 subunit
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持