SML2445
PKS21004
≥98% (HPLC)
别名:
(2S)-N1-[2-[([1,1′-biphenyl]-3-ylcarbonyl)amino]ethyl]-N4-(1,1-dimethylethyl)-2-[(1-oxo-3-phenylpropyl)amino]-butanediamide
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N[C@@H](CC(NC(C)(C)C)=O)C(NCCNC(C1=CC=CC(C2=CC=CC=C2)=C1)=O)=O)CCC3=CC=CC=C3
InChI
1S/C32H38N4O4/c1-32(2,3)36-29(38)22-27(35-28(37)18-17-23-11-6-4-7-12-23)31(40)34-20-19-33-30(39)26-16-10-15-25(21-26)24-13-8-5-9-14-24/h4-16,21,27H,17-20,22H2,1-3H3,(H,33,39)(H,34,40)(H,35,37)(H,36,38)/t27-/m0/s1
InChI key
ZMFRLEFFYGXGES-MHZLTWQESA-N
Biochem/physiol Actions
PKS21004 is highly selective, potent and reversible inhibitor of the Plasmodium falciparum proteasome (Pf20S) β5 subunit. It is not active against mammalian c-20S and i-20S proteasome subunits. PKS21004 is effective against erythrocytic, sexual, and liver-stage parasites. Also it is active against parasites resistant to current antimalarials, and strains from patients in Africa.
highly selective, potent and reversible inhibitor of the Plasmodium falciparum proteasome (Pf20S) β5 subunit
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有