SML2455
MEPB
≥98% (HPLC)
别名:
2-((2-phenoxyethyl)thio)-1-(2-(p-tolyloxy)ethyl)-1H-benzo[d]imidazole
InChI
1S/C24H24N2O2S/c1-19-11-13-21(14-12-19)27-16-15-26-23-10-6-5-9-22(23)25-24(26)29-18-17-28-20-7-3-2-4-8-20/h2-14H,15-18H2,1H3
InChI key
PNCBJXVNIRRHJP-UHFFFAOYSA-N
SMILES string
CC(C=C1)=CC=C1OCCN2C(SCCOC3=CC=CC=C3)=NC4=CC=CC=C42
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
MEPB is a modulator of the activation function-2 (AF-2) of the androgen receptor (AR), increasing AR co-repressor binding. MEPB specifically binds the BF3 pocket of the androgen receptor where it modulates binding of co-regulators to the AF2 domain. MEPB was found to rescue degeneration in a mouse model of spinal bulbar muscular atrophy, a motor neuron disease caused by toxic gain of function of the androgen receptor.
Modulator of the activation function-2 (AF-2) of the androgen receptor (AR)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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