SML2494
Pralatrexate
≥98% (HPLC), DHFR inhibitor, powder
别名:
(2S)-2-[[4-[(1RS)-1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic acid, 10-propargyl-10-deazaaminopterin, N-(4-{1-[(2,4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic acid, PDX
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关于此项目
经验公式（希尔记法）:
C23H23N7O5
化学文摘社编号:
分子量:
477.47
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
Pralatrexate, ≥98% (HPLC)
InChI
1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1
SMILES string
O=C([C@@H](NC(C1=CC=C(C(CC(N=C23)=CN=C3N=C(N=C2N)N)CC#C)C=C1)=O)CCC(O)=O)O
InChI key
OGSBUKJUDHAQEA-WMCAAGNKSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Potent DHFR inhibitor; antifolate; antineoplastic;
Pralatrexate is an antifolate that selectively enters cancer cells expressing reduced folate carrier type 1 (RFC-1). Pralatrexate potently inhibits DHFR (dihydrofolate reductase).
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jennifer E Amengual et al.
Blood, 131(4), 397-407 (2017-11-17)
Peripheral T-cell lymphomas (PTCL) are a group of rare malignancies characterized by chemotherapy resistance and poor prognosis. Romidepsin and pralatrexate were approved by the US Food and Drug Administration for patients with relapsed/refractory PTCL, exhibiting response rates of 25% and
Enrica Marchi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(24), 6657-6661 (2013-08-24)
Folates are well known to be essential for many cellular processes, including cellular proliferation. As a consequence, antifolates, the fraudulent mimics of folic acid, have been shown to be potent therapeutic agents in many cancers. Over the past several decades
Owen A O'Connor et al.
Leukemia & lymphoma, 58(11), 2548-2557 (2017-07-26)
It has been nearly 8 years since pralatrexate became the first drug approved by the U.S. Food and Drug Administration for the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL). Like most drugs approved for a particular clinical indication
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