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Merck
CN

SML2519

Anamorelin

≥98% (HPLC)

别名:

2-Amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide, ONO-7643, RC-1291, ST-1291

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关于此项目

经验公式（希尔记法）:
C31H42N6O3
化学文摘社编号:
249921-19-5
分子量:
546.70
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD11973671

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SMILES string

N3(C[C@@](CCC3)(Cc4ccccc4)C(=O)N(N(C)C)C)C(=O)[C@H](NC(=O)C(N)(C)C)Cc1c2c([nH]c1)cccc2

InChI

1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1

InChI key

VQPFSIRUEPQQPP-MXBOTTGLSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

相关类别

Biochem/physiol Actions

Anamorelin is a non-peptidic ghrelin mimetic and growth hormone (GH) secretagogue. It is an orally-active, brain-penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). Anamorelin has been shown to increases appetite, overall body weight, lean body mass, and muscle strength in clinical studies with cancer patients suffering from cachexia.
Ghrelin receptor agonist

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000403339
0000403339
0000192447
0000192446
0000192447

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Palliative care: Anamorelin provides benefit to patients with cachexia.
Peter Sidaway
Nature reviews. Clinical oncology, 15(2), 68-68 (2017-12-20)
Nobuyuki Katakami et al.
Cancer, 124(3), 606-616 (2017-12-06)
Cachexia, described as weight loss (mainly in lean body mass [LBM]) and anorexia, is common in patients with advanced cancer. This study examined the efficacy and safety of anamorelin (ONO-7643), a novel selective ghrelin receptor agonist, in Japanese cancer patients
S C Gross et al.
Orthopedics, 12(12), 1561-1564 (1989-12-01)
From 1968 to 1987, 22 patients were diagnosed with dysfunctioning digits after complete distal digital amputations. Each patient had the proximal portion of the partially amputated phalanx left within the injured digit. On average, 21 months after the initial injury

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