SML2524
Fexinidazole
≥98% (HPLC)
别名:
1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole, HOE 239
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关于此项目
经验公式（希尔记法）:
C12H13N3O3S
化学文摘社编号:
分子量:
279.31
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
light yellow to dark brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
CN1C(COC2=CC=C(SC)C=C2)=NC=C1[N+]([O-])=O
InChI
1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3
InChI key
MIWWSGDADVMLTG-UHFFFAOYSA-N
Biochem/physiol Actions
Anti Trypanosoma, Leishmania agent.
Fexinidazole is a potent anti-Trypanosoma agent. Trypanosoma species human protozoan pathogens are responsible for sleeping sickness and Chagas disease. In vivo, fexinidazole is oxidized to sulfoxide and sulfone metabolites that are effective in blocking the progression of the parasitic disease visceral leishmaniasis. The mechanism of action appears to be by reductive activation via an NADH-dependent nitroreductase expressed by the parasites.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable