SML2544
NSC49652
≥98% (HPLC)
别名:
(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one, (E)-1-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-2-propen-1-one
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关于此项目
经验公式（希尔记法）:
C14H11NO2
化学文摘社编号:
分子量:
225.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O
InChI
1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+
InChI key
CRWNZUBUBIULHB-BQYQJAHWSA-N
Biochem/physiol Actions
NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) that targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.
orally active, potent and selective inhibitor of death receptor p75NTR that targets the interfaces between transmembrane domains
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable