SML2544
NSC49652
≥98% (HPLC)
别名:
(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one, (E)-1-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-2-propen-1-one
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O
InChI
1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+
InChI key
CRWNZUBUBIULHB-BQYQJAHWSA-N
生化/生理作用
NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) that targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.
orally active, potent and selective inhibitor of death receptor p75NTR that targets the interfaces between transmembrane domains
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Eddy T H Goh et al.
Cell chemical biology, 25(12), 1485-1494 (2018-10-09)
Small molecules offer powerful ways to alter protein function. However, most proteins in the human proteome lack small-molecule probes, including the large class of non-catalytic transmembrane receptors, such as death receptors. We hypothesized that small molecules targeting the interfaces between
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