SML2556
Pt-ttpy
>97% (NMR)
别名:
(SP-4-2)-Chloro[4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine-κN1,κN1′,κN1′′]-Platinum(1+) chloride, Tolylterpyridin-platin
form
powder
InChI
1S/C22H17N3.2ClH.Pt/c1-16-8-10-17(11-9-16)18-14-21(19-6-2-4-12-23-19)25-22(15-18)20-7-3-5-13-24-20;;;/h2-15H,1H3;2*1H;/q;;;+2/p-2
InChI key
UWAUJHRZLKCPPX-UHFFFAOYSA-L
SMILES string
CC1=CC=C(C2=CC(C3=[N+]4C=CC=C3)=[N+]5C(C6=CC=CC=[N+]6[Pt-2]54Cl)=C2)C=C1.[Cl-]
assay
>97% (NMR)
color
faint yellow to dark orange
solubility
DMSO: 0.2 mg/mL (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells
Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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