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SML2561

ML162

Name: ML162
Brand: SIGMA

≥98% (HPLC), glutathione peroxidase inhibitor, powder

别名:

α-[（2-氯乙酰基）（3-氯-4-甲氧基苯基）氨基]-N-（2-苯乙基）-2-噻吩乙酰胺, 2-氯-N-（3-氯-4-甲氧基苯基）-N-（2-氧代-2-（苯乙基氨基）-1-（噻吩-2-基）乙基）乙酰胺, BRD-5421, BRD5421, CID 3689413, ML 162, ML-162, 分子库162

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关于此项目

经验公式（希尔记法）:

C₂₃H₂₂Cl₂N₂O₃S

化学文摘社编号:

1035072-16-2

分子量:

477.40

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD03450805

Assay:

≥98% (HPLC)

Form:

powder

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产品名称

ML162, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to very dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c(ccc1)C(N(c3cc(c(cc3)OC)Cl)C(=O)CCl)C(=O)NCCc2ccccc2

InChI

1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)

InChI key

UNVKYJSNMVDZJE-UHFFFAOYSA-N

Biochem/physiol Actions

ML162是一种小分子，可通过共价抑制细胞磷脂谷胱甘肽过氧化物酶（GPx-4；GPx4；GSHPx-4；PHGPx；SNGPx；snPHGPx）诱导铁死亡。癌症培养物中的合成致死性研究确定了诸如HRas（G12V）表达和富马酸水合酶（FH）缺失对ML162敏感性的影响因子（在BJeLR-HRas（G12V）&UOK262-FH-/-培养物中IC50分别为25 nM & 35 nM）。

共价磷脂谷胱甘肽过氧化物酶（GPx4；GSHPx-4；PHGPx；SNGPx；snPHGPx）抑制剂，可诱导铁死亡。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000224211

0000167977

0000119328

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