SML2562
Raphin1
≥98% (HPLC)
别名:
2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide, N-(2, 3-Dichlorobenzylideneamino) guanidine, Rational inhibitor of a holophosphatase1
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关于此项目
经验公式（希尔记法）:
C8H8Cl2N4
化学文摘社编号:
分子量:
231.08
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
SMILES string
Clc1c(cccc1\C=N\N=C(N)N)Cl
InChI
1S/C8H8Cl2N4/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
InChI key
WLTSTDGGFCQWTK-YIXHJXPBSA-N
Biochem/physiol Actions
Raphin1 is an orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B). It does not inhibit PP1c. Raphin1 transiently decreases protein synthesis in cells. It is efficacious in mouse model of Huntington′s disease.
orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable