SML2573
MitoCDNB
≥98% (HPLC), mitochondrial thiol redox inactivator, powder
别名:
[4-(5’-Chloro-2’,4’-dinitrophenylamino)but-1-yl]triphenylphosphonium methanosulfonate
产品名称
MitoCDNB, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to very dark brown
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
MitoCDNB is a mitochondrially selective inactivator of mitochondrial thiol redox homeostasis in isolated cells and in vivo. MitoCDNB selectively depletes the mitochondrial reduced glutathione (GSH) pool by formation of MitoGSDNB and dramatically increasing absorbance at 328 nm. It directly inhibits mitochondrial thioredoxin TrxR2 and peroxiredoxin 3.
mitochondrially selective inactivator of mitochondrial thiol redox homeostasis in isolated cells and in vivo
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lee M Booty et al.
Cell chemical biology, 26(3), 449-461 (2019-02-05)
Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell. While maintenance of mitochondrial thiol redox state is thought vital for cell survival, this was not testable due to the difficulty of manipulating the organelle's
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