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经验公式(希尔记法):
C21H25N · HCl
化学文摘社编号:
分子量:
327.89
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
美利曲辛 盐酸盐, ≥98% (HPLC)
SMILES string
[Cl-].[N+H](CCC=C1c2c(cccc2)C(c3c1cccc3)(C)C)(C)C
InChI
1S/C21H25N.ClH/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21;/h5-8,10-14H,9,15H2,1-4H3;1H
InChI key
RADLXCPDUXFGFF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
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Biochem/physiol Actions
Melitracen is a tricyclic antidepressant (TCA) that likely exerts its in vivo efficacy similarly as imipramine and amitriptyline by inhibiting serotonin-norepinephrine reuptake.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xiu-Juan Yan et al.
World journal of gastroenterology, 21(15), 4652-4659 (2015-04-29)
To explore whether clinician-patient communication affects adherence to psychoactive drugs in functional dyspepsia (FD) patients with psychological symptoms. A total of 262 FD patients with psychological symptoms were randomly assigned to four groups. The patients in Groups 1-3 were given
[The thymoleptic efficacy represented by melitracen].
D Bente et al.
Arzneimittel-Forschung, 16(2), 319-321 (1966-02-01)
Studies on the metabolism of Melitracen (N 7001) in rats.
I Eberholst et al.
Arzneimittel-Forschung, 16(7), 876-878 (1966-07-01)
The pharmacological properties of melitracen (N 7001) and litracen (N 7049).
I M Nielsen et al.
Arzneimittel-Forschung, 16(2), 135-140 (1966-02-01)
Relationship between the restriction of food intake and Melitracen, an antidepressant, in the rat.
K Shimamoto et al.
Acta Scholae Medicinalis Universitatis in Kioto, 40(1), 25-37 (1967-07-01)
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