SML2606
Bragsin2
≥98% (HPLC)
别名:
6-Methoxy-5-nitro-2-(trifluoromethyl)-4H-1-benzopyran-4-one
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关于此项目
经验公式（希尔记法）:
C11H6F3NO5
化学文摘社编号:
分子量:
289.16
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC(F)(F)c1[o]c2c([c](c1)=O)c(c(cc2)OC)[N+](=O)[O-]
InChI key
WJUILHMXVGFAIS-UHFFFAOYSA-N
Biochem/physiol Actions
Bragsin2 is a hydration resistant cell penetrant, potent and selective noncompetitive inhibitor of ArfGEF BRAG2 (Afr guanine nucleotide exchange factor BRAG2) that inhibits Arf GTPase activation in vitro and in cells. It binds to pleckstrin homology (PH) domain of BRAG2 and misposition BRAG2 on the membrane. Bragsin2 disrupt the function of the yeast ArfGEF Sec7p. Bragsin2 suppresses tumorsphere formation of some breast cancer stem cell lines including SUM149 and S68.
cell penetrant, potent and selective noncompetitive inhibitor of ArfGEF BRAG2
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Agata Nawrotek et al.
Nature chemical biology, 15(4), 358-366 (2019-02-12)
Peripheral membrane proteins orchestrate many physiological and pathological processes, making regulation of their activities by small molecules highly desirable. However, they are often refractory to classical competitive inhibition. Here, we demonstrate that potent and selective inhibition of peripheral membrane proteins