SML2611
Bobcat339
≥98% (HPLC), TET1 and TET2 inhibitor, powder
别名:
1-([1,1′-联苯基]-3-基)-4-氨基-5-氯吡啶-2(1H)-酮, 4-氨基-1-[1,1′-联苯基]-3-基-5-氯-2(1H)-嘧啶酮
产品名称
Bobcat339, ≥98% (HPLC)
InChI
1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21)
InChI key
QMGYGOOYCNTEQO-UHFFFAOYSA-N
SMILES string
NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
Bobcat339是TET1和TET2[10-11易位甲基胞嘧啶双加氧酶（TET）1和2]的细胞渗透性，有效和选择性抑制剂，可降低培养的神经元中5-羟甲基胞嘧啶（5hmC）的含量。Bobcat339不抑制DNMT3A。
细胞渗透剂，TET1和TET2的有效和选择性抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Gabriella N L Chua et al.
ACS medicinal chemistry letters, 10(2), 180-185 (2019-02-21)
DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered neuronal plasticity
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