SML2659
Spastazoline
≥98% (HPLC)
别名:
(R)-N-(5-(tert-butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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关于此项目
经验公式（希尔记法）:
C20H30N8
化学文摘社编号:
分子量:
382.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[nH]1nc(cc1Nc2nc(nc4[nH]ccc42)N3C[C@H](NCC3)C(C)C)C(C)(C)C
InChI
1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)/t14-/m0/s1
InChI key
HNOLTAKAPDKZRY-AWEZNQCLSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Spastazoline is a cell penetrant, potent and selective ATP-competitive inhibitor of spastin.
cell penetrant, potent and selective ATP-competitive inhibitor of spastin
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Rudolf Pisa et al.
Journal of the American Chemical Society, 141(14), 5602-5606 (2019-03-16)
The bump-hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structural data for inhibitor-protein complexes
Tommaso Cupido et al.
Nature chemical biology, 15(5), 444-452 (2019-02-20)
Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellular processes. To design a chemical inhibitor of
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